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Vitamin D and Probiotics the great Relationship

Tigosol is a triple complex food supplement, a “super-fighter” for our immune system. Tigosol combines all the benefits of vitamin D with the excellent probiotic properties of Bacillus subtilis and the remarkable antioxidant properties of epigallocatechin-3-gallate (EGCG), a polyphenol extracted from green tea. The following, in depth, report was compiled from referenced scientific resources to explain exactly how you too may benefit from Tigosol.   

Where is my sunshine?

Vitamin D (calciferol) are a group of compounds with a similar structure, of which the most important are vitamins D2 (ergocalciferol) and D3 (cholecalciferol). Vitamin D2 and D3 are physiologically active forms of vitamin D (referred to as calciferol) which are synthesized in liver and kidney after our skin has been exposed to sunlight.

Vitamin D is one of the essential vitamins for human health. It is a fat-soluble vitamin, a precursor of a hormone that the body creates during sun exposure but can also get it from certain food and supplements. The Potential health benefits of vitamin D are becoming increasingly apparent. Studies suggest that continued vitamin D deficiency (˂20 ng/ml) may be in a line with numerous health issues like metabolic and autoimmune disorders, multiple sclerosis, cardiovascular disease and diabetes or even cancer.

Vitamin D is crucial for stimulation of intestine

to absorb calcium and phosphorus for maintaining healthy bones, teeth and muscles because calcium can only be absorbed when vitamin D is present. Vitamin D maintains the integrity of the intestinal mucosal barrier and its deficiency results in chronic dysbiosis (a disturbance of the balance between good and bad bacteria in the gut) and the potential passage of pathogenic intestinal bacterial products from the intestinal lumen into the circulation. This impairs normal digestion and creates the condition for systemic and chronic inflammation which, over time, disrupts functioning of the immune system and also neurological functions. There is often talk about the link between intestinal health, the amount of fiber and vitamin D in the diet and the occurrence of neurodegenerative disorders, especially Parkinson’s disease.Sufficient sunlight helps the body to produce vitamin D. However, season, time of day, cloud cover, latitude, smog, skin pigmentation, and sunscreen are among the factors that affect UV radiation exposure and vitamin D synthesis. Also, vitamin D breaks down quite quickly, meaning that it can easily run low, especially in the winter. There is evidence and good reasons for adequate vitamin D intake during all stages of life.  Vitamin D levels from 20 to 30 ng/ml are considered the minimum.There is evidence and good reasons for adequate vitamin D intake during all stages of life.  Vitamin D levels from 20 to 30 ng/ml are considered the minimum.There is evidence and good reasons for adequate vitamin D intake during all stages of life.  Vitamin D levels from 20 to 30 ng/ml are considered the minimum.

Heeelp! My gut is talking to me!

The human microbiota is a collective term for the micro-organisms that live in or on the human body. It is made up of millions of bacteria, fungi and viruses, with over 1,000 different species. The biggest microbiota community inhabit in the gut and every person has a unique combination of species in a symbiotic relationship that benefit the human. Gut microbiota has a crucial role in maintaining host physiology, metabolic and immune homeostasis. It is evident nowadays that gut microbiota evolves with us and that any changes in this convoluted and complex community affect host welfare. Also, any health disturbance of host organism affects gut microbiota homeostasis. It is said that gut is our second brain, so-called enteric nervous system (ENS) with millions of nerve cells lining our gastrointestinal tract.Researchers are finding evidence that this system communicates with our brain and triggers changes in our physical and emotional health, creating a strong link between digestion and mood. Usage of probiotics with well-being has a long history. 

Benefits of Probiotics

Benefits of probiotics are attributed mainly to the antimicrobial substances produced by probiotic bacteria and prevent invasion and protect the host against toxins, thus altering the profile and functions of the gut microbiome. As stated by Food and Agriculture Organization (FAO) and World Health Organization (WHO) guidelines, probiotic organisms used in food should be capable of surviving passage through the digestive tract and have the capability to proliferate and colonize the gut and to resist gastric juices and exposure to bile. As stated by Food and Agriculture Organization (FAO) and World Health Organization (WHO) guidelines, probiotic organisms used in food should be capable of surviving passage through the digestive tract and have the capability to proliferate and colonize the gut and to resist gastric juices and exposure to bile. As stated by Food and Agriculture Organization (FAO) and World Health Organization (WHO) guidelines, probiotic organisms used in food should be capable of surviving passage through the digestive tract and have the capability to proliferate and colonize the gut and to resist gastric juices and exposure to bile.

 Bacillus subtilis is a Gram-positive spore-forming bacterium with numerous characteristics contrasting vegetative cells. Its spores are extremely resistant to desiccation and high temperatures and tolerate a wide range of pH what makes them an excellent probiotic candidate. These characteristics allowing Bacillus subtilis to be stored and stable as dried powder formulation and to pass through the gastrointestinal system and efficiently express its beneficial effects.

ProbioD-fence a cross-link Relationship

Recent researches and published studies imply health benefits of probiotics and vitamin D co-supplementation. There are numerous studies indicating a synergistic effect of vitamin D and probiotics on many metabolic disorders. These two create a crosslink relationship. The basis of this synergism relies on probiotic effect boosting vitamin D level (2) and improving the expression of vitamin D receptors (3). Vitamin D receptors are located on the surface of intestinal epithelial cells, especially in the colon. Furthermore, recent researches show that vitamin D and its receptor contribute to the protective process of probiotics. Oral probiotic supplementation may affect that more vitamin D is being absorbed or that more its precursors in being synthesized. On the other hand,vitamin D receptor plays a vital role in the effect of probiotic protection against inflammation and infection.

Foods naturally contain vitamin D

are fatty fish (salmon, tuna…), fish liver oils, beef liver, egg yolks, soy, almond and oat milk, and mushrooms. On the other hand, probiotics can be found in yoghurt, kefir, kimchi or other fermented foods. But sometimes food is not enough and many people don’t have a balanced diet or their diet doesn’t provide them with all the nutrients they need. This is particularly important in autumn and winter months when there is reduced sunlight as well as lack of fresh fruits and vegetables so there is a need for dietary supplementation.

By the definition in Directive 2002/46/EC of the European Parliament and of the Council, food supplement is defined as foodstuff that is meant to supplement the normal diet and which is concentrated sources of nutrients or other substances with a nutritional or physiological effect, alone or in combination, where nutrients could be vitamins, minerals, herbal extracts and other ingredients.

Benefits for Mental Health?

Journal of Ovarian Research recently published a study indicating that the vitamin D and probiotic co-supplementation has beneficial effects on mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome (1). A study published 2016 (4) in Nature Genetics indicates that human vitamin D receptor is the key host factor to shape the gut microbiome. An impact of vitamin d and probiotics on mental health performed in a randomized placebo-controlled trial with chronic schizophrenia patients (5) showed that probiotic and vitamin D for 12 weeks had ameliorated effects on the general and metabolic profiles.Using vitamin D and probiotic supplementation could affect a reduction in serum insulin levels and serum HDL cholesterol levels along with increasing serum antioxidant capacity. Combined probiotic and vitamin D supplementation showed beneficial effects on the metabolic status of women with gestational diabetes (GDM) as showed by randomized, double-blind, placebo-controlled clinical trial performed in 87 women with GDM (6).

Source

References:

  1. Ostadmohammadi V, Jamilian M, Bahmani F, Asemi Z. Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome. J Ovarian Res. 2019 Jan 21;12(1):5. doi: 10.1186/s13048-019-0480-x. PMID: 30665436; PMCID: PMC6340184.
  2. Jones ML, Martoni CJ, Prakash S. Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial. J Clin Endocrinol Metab. 2013 Jul; 98(7):2944-51.
  3. Shang M, Sun J. Review Vitamin D/VDR, Probiotics, and Gastrointestinal Diseases. Curr Med Chem. 2017; 24(9):876-887.
  4. Wang J, Thingholm Louise B, Skiecevičienė Jurgita, Rausch Philipp, Kummen Martin, Hov Johannes R, Degenhardt Frauke, Heinsen Femke-Anouska, Rühlemann Malte C, Szymczak Silke, Holm Kristian, Esko Tönu, Sun Jun, Pricop-Jeckstad Mihaela, Al-Dury Samer, Bohov Pavol, Bethune Jörn, Sommer Felix, Ellinghaus David, Berge Rolf K, Hübenthal Matthias, Koch Manja, D’Amato Mauro, Cloppenborg-Schmidt Katja, Künzel Sven, Laudes Matthi-as, Marschall Hanns-Ulrich, Lieb Wolfgang, Nöthlings Ute, Karlsen Tom H, Baines John F, Franke Andre. Genome-wide host-microbiota association analysis of 1,812 individuals identifies vitamin D receptor genetic variation and other host factors shaping the gut microbiota. Nature Genetics. 2016; Manuscript Number: NG-A43458.
  5. Ghaderi A, Banafshe HR, Mirhosseini N. et al.Clinical and metabolic response to vitamin D plus probiotic in schizophrenia patients. BMC Psychiatry19, 77; 2019. https://doi.org/10.1186/s12888-019-2059-x
  6. Jamilian M, Amirani E, Asemi Z. The effects of vitamin D and probiotic co-supplementation on glucose homeostasis, inflammation, oxidative stress and pregnancy outcomes in gestational diabetes: A randomized, double-blind, placebo-controlled trial. Clinical Nutrition, 2019; https://doi.org/10.1016/j.clnu.2018.10.028

The statements made within this website have not been evaluated by the U.S. Food and Drug Administration. These statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.

Legal Disclaimer 

Please consult your physician before implementing any new diet, exercise and dietary supplement programs, especially if you have pre existing medical conditions or are taking prescribed medications. The statements made on this website are for educational purposes only and are not meant to replace the advice of your physician or healthcare provider.

5 REASONS TO REPLACE YOUR COFFEE WITH GREEN TEA

Coffee is the most popular morning drink, a beloved habit, a little ritual, and maybe a slight addiction. For many, right after waking up, the first thing to do is brew a cup of coffee. However, there is often a sudden drop in energy, which is why we always quickly grab a second cup. Why is that? Is there a healthier alternative to consuming coffee?

1. GREEN TEA EXTRACT GIVES STABLE ENERGY

Though we hate to admit it, caffeine is addicting. .However, while caffeine is known to make you feel awake, it doesn’t boost your energy levels. Instead, it only peaks for a short time, and then the energy is gone.

Green tea and its extract contain less caffeine compared to coffee. Green tea extract has a smaller dose of caffeine and L-theanine and therefore are a much milder but more stable “energy injections” than coffee.

2. EGCG SUPPORTS HEART HEALTH

Some research has shown that large amounts of coffee are linked to a slight rise in cholesterol, increasing the risk of heart disease.

In contrast to coffee, the EGCG from green tea can protect your body. Research has shown that it can improve blood flow, which is extremely important for the heart to function, and it can even help to lower cholesterol.

Both coffee and green tea are antioxidants. Both behave differently, as previously mentioned, with the heart and cholesterol.  As studies show, Green tea is a powerful antioxidant due to its composition of valuable ingredients and beneficial polyphenols. According to research, green tea extract stimulates the metabolism and helps burn fat.

4. EGCG AS BRAINFOOD

Coffee as well as green tea support memory and concentration. The difference here is that the effects of coffee may be more robust but also much shorter. In contrast, green tea, according to numerous studies, gives longer-lasting brain, concentration, and memory improving results.

5. EGCG AND GREEN TEA AS BEAUTY BOOSTERS

Did you know that coffee can hurt sleep quality? If you drink coffee in large quantities, it can even cause insomnia. Lack of sleep can influence the skin’s freshness; we can get dark circles under the eyes, etc. In contrast, the intake of green tea extract can help to reduce anxiety and improve sleep.

Coffee also contains chromogens and tannins, which can turn your teeth yellow by discoloring tooth enamel. It is also high in acidity. The result: tooth decay! Conversely, green tea can kill and eliminate bacteria in oral cavitie and at the same time remove unpleasant odors.

Have you thought, at times it would be good to replace coffee with green tea, but lacked the motivation? Or maybe you didn’t even know that green tea could be a healthier option than your morning espresso? We hope this information inspires you to try it out for yourself right now. Change your habits, accept the challenge and do something good for your health!

tigovit green tea complex: The simplest and most convenient way to take green tea!

One capsule of tigovit is roughly equivalent to four cups of green tea, enriched with ingredients such as polyphenols and flavonoids.

The added Ester-C, a particularly high-quality vitamin C, contributes to the normal function of the immune system (physical defense).

Supports Healthy Heart, Metabolism & Energy with Polyphenols
Green Tea Extract Supports Cellular Health, Supports Brain Function, Natural Energy Boost, Metabolism Support, and Rich in Antioxidants

The statements made within this website have not been evaluated by the U.S. Food and Drug Administration. These statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease. Follow the CDC Guidelines

Legal Disclaimer 

Please consult your physician before implementing any new diet, exercise and dietary supplement programs, especially if you have pre existing medical conditions or are taking prescribed medications. The statements made on this website are for educational purposes only and are not meant to replace the advice of your physician or healthcare provider.

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